22 (TIE). Built in the 1920s for cotton heir Otto Dommerrich, this Upper East Side mansion has been used as a medical facility for the last several decades, but it's now on the market as a single-family home.
Price: $72 million
The townhome has more than 21,000 square feet of space spread out over seven stories. It still has its original Beaux Arts limestone facade, as well as many other original design details.
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