Hubert de Givenchy had Audrey Hepburn. Yves Saint Laurent had Betty Catroux. For decades, the designer-muse relationship has inspired iconic fashion moments both on and off the runway (who can forget Hepburn's Little Black Givenchy Dress in Breakfast at Tiffany's? Or, for that matter, the cone bra Jean Paul Gaultier designed for his muse, Madonna, for her 1990 Blonde Ambition tour?). These days, with a new wave of models, musicians, and multi-hyphenates taking the stage, whether literally or on social media, the role of "muse" is a little more amorphous - but nonetheless fruitful. Click through for the icons on-the-rise in the fashion world and beyond.

[Photo via @oyinda/t.a. New York]