Per Se
This might be the most expensive on the list. With some entrees alone costing upwards of $125, and the prix fixe starting at $310 without supplements, you'll definitely be spending a lot. But you get what you pay for. Their prix fixe is a nine course eating experience where no single ingredient is repeated throughout the meal. The dishes that are brought out of the kitchen are truly works of art, using different shapes and sizes, and truly transforming the ingredients into things unrecognizable.
Find Per Se on the 4th floor at Ten Columbus Circle 60th St.
[Photo via @perseny]